BioChiol
| INCI Name | Bakuchiol |
|---|---|
| Chemical Name | Phenol, 4-[(1E,3S)-3-ethenyl-3, 7-demethyl-1, 6 –octadienyl] |
| CAS # | 10309-37-2 |
| Origin | 100% Natural, Extracted and purified from edible seed kernels |
| Appearance | Yellow to yellowish brown liquid |
| Purity | 98% min. (typically>99%) |
| Solubility/Miscibility | Miscible with a wide-range of Hydrophobic emollients |
| Stability | Photochemically & Hydrolytically stable |
| Suggested use level | 0.5 to 1% |
| Storage | Store in original sealed container at +10 to 30 degree C; avoid exposure to light & heat |
| Regulatory | Approved for use in all major countries |
| Formulation guidelines | It is a Lipophilic compound miscible in a wide variety of emollients, such as, caprylic/capric triglycerides, ethyl linoleate, C12-15 alkyl benzoates, squalene, jojoba oils, olive oils, etc.it can be easily formulated into creams, lotions, oils, serums, hydro-alcoholic sprays, etc. |
| a) At a level of 0.5 to 1.0% w/w of finished formulation | |
| b) The formulation after making emulsion with a processing temperature of about 50 degree C. Alternately, it can be included in the oil phase | |
| c) Addition of small amount of a chelating agent (0.05%) is helpful in overcoming coloration issue due to the presence of iron or copper | |
| d) The finished product must be acidic, preferable having pH below 6 and must be protected from prolong exposure to heat and light for maintaining product integrity over time. |
| Product Name | BioChiol |
|---|---|
| Botanical Name | Psoralea corylifolia L. |
| Plant part | Seeds |
| Active ingredient | Bakuchiol |
| Chemical formula | C18H24O |
| Molecular weight | 256.38 g/mol |
| Shelf life | 5 Years |
| S. No | Parameters | Specification |
|---|---|---|
| Physical | ||
| 1 | Description | Light brown to honey color viscous liquid |
| 2 | Identification by TLC | To match with reference standard pattern |
| 3 | Moisture by KF | NMT 1.0% |
| 4 | Solubility | Soluble in Alcohol & DMSO |
| Chemical | ||
| 5 | % Assay by HPLC content Bakuchiol | NLT 99.0% w/w on dry basis |
| 6 | Related substances by HPLC Content of Psoralen & Angelicin |
NMT 20 ppm |
| Others | ||
| 7 | Heavy Metals | NMT 10.0ppm |
| Lead | NMT 3.0ppm | |
| Arsenic | NMT 1.0ppm | |
| Cadmium | NMT 0.3ppm | |
| Mercury | NMT 0.1ppm | |
| 8 | Residual solvents | Should comply by ICH/USP |
| 9 | Residual Pesticides | To comply as USP for Botanicals |
| Microbiological Profile | ||
| 10 | Total plate count | NMT 1000 cfu/g |
| Yeast and molds count | NMT 100cfu/g | |
| Escherichia coli | Absent /10g | |
| Salmonella | Absent /10g | |
| Staphylococcus aureus | Absent /10g | |
| Pseudomonas aeruginosa | Absent /10g | |
| Additional information | ||
| Storage Condition | Store at room temperature | |
| Allergen Statement | Free from Allergen | |
| GMO status | GMO free | |
| Sanitizing treatment | Non-irradiated & Not treated with ETO | |
| Since the product is derived from Natural origin, there is likely to be minor color variation because of the geographical & seasonal variations of the source of raw material | ||
Section 1: CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
| Product Name: | BioChiol |
|---|---|
| CAS#: | 10309-37-2 |
| RTECS: | Not available. |
| TSCA: | TSCA 8(b) inventory: No products were found. |
| EINECS No: | -NA- |
| Synonym: | Bakuchiol 99% |
| Contact Information: | |
|---|---|
| Bio-India Biologicals (BIB) Corporation Plot No. 16, 2nd Floor, Akbar Road,Diamond Point, Sikh Village, Hyderabad – 500 009 | |
| Tel: | 0091 9392485187 |
| Email: | info@bibcorporation.com |
Section 2: COMPOSITION AND INFORMATION ON INGREDIENTS
| SUBSTANCES | |
|---|---|
| Synonyms : | 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-phenol |
| Formula : | C18H24O |
| Molecular weight : | 256.38 g/mol |
| CAS-No. : | 10309-37-2 |
| No components need to be disclosed according to the applicable regulations. | |
| Toxicological Data on Ingredients: There are no known hazardous substances containing in this product. |
Section 3: HAZARDS IDENTIFICATION
CLASSIFICATION OF THE SUBSTANCE OR MIXTURE
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
LABEL ELEMENTS
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
OTHER HAZARDS
This substance/mixture contains no components considered to be persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Section 4: FIRST AID MEASURES
GENERAL ADVICE:
Consult a physician. Show this safety data sheet to the doctor in attendance.
IN CASE OF EYE CONTACT:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.
IN CASE OF SKIN CONTACT:
Due to its use in cosmetics, no adverse effects are expected
IN CASE OF SERIOUS SKIN CONTACT:
Wash off with soap and plenty of water. Consult a physician.
IN CASE OF INHALATION:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
IN CASE OF INGESTION:
Do Not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
Section 5: FIRE AND EXPLOSION DATA
| Extinguishing procedures : | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
|---|---|
| Protective Equipment : | Wear self-contained breathing equipment and Protective suit. |
| Hazardous Products of Combustion : | Carbon oxides |
| Special Firefighting procedures : | No data available |
Section 6: ACCIDENTAL RELEASE MEASURES
PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES
Use personal protective equipment. Avoid breathing vapours, mist or gas. For personal protection see section 8.
ENVIRONMENTAL PRECAUTIONS
Do not let product enter drains.
METHODS AND MATERIALS FOR CONTAINMENT AND CLEANING UP
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
REFERENCE TO OTHER SECTIONS
For disposal see section 13.
Section 7: HANDLING AND STORAGE
PRECAUTIONS
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk; evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust.
STORAGE
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Store under room temperature not exceeding 25oC.
HANDLING
No restrictions
Suitable packing material
Aluminum/SS Containers, tightly sealed container
Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
EXPOSURE CONTROLS
APPROPRIATE ENGINEERING CONTROLS
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
PERSONAL PROTECTIVE EQUIPMENT
EYE/FACE PROTECTION
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
SKIN PROTECTION
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
BODY PROTECTION
Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace
RESPIRATORY PROTECTION
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Section 9: PHYSICAL AND CHEMICAL PROPERTIES
| Physical state : | Light brown to honey color viscous liquid |
|---|---|
| Moisture by KF : | NLT 1.0% |
| Solubility : | Soluble in Alcohol and DMSO |
| Initial boiling point and boiling range : | 145 - 147 °C |
| Relative density : | 0.96 g/cm3 at 20 °C at 1013 hPa |
| Flash point : | 108 °C - Closed cup |
| Further information refers COA. |
Section 10: STABILITY AND REACTIVITY DATA
| Conditions to avoid : | High temperature& high humidity. |
|---|---|
| Incompatibility : | Incompatible with strong acids, alkalis and oxidizing agents |
| Hazardous decomposition : | None (Biodegradable) |
| Chemical Stability : | Stable under recommended storage conditions |
Section 11: TOXICOLOGICAL INFORMATION
INFORMATION ON TOXICOLOGICAL EFFECTS
ACUTE TOXICITY
LD50 Oral - Rat - 2560,0 mg/kg
LD50 Intraperitoneal - Mouse - 94 mg/kg
LD50 Intravenous - Mouse - 31 mg/kg
SKIN CORROSION/IRRITATION
Skin - Human
Result: No skin irritation
(Patch Test 24 Hrs. on humans: No detectable irritation.)
SERIOUS EYE DAMAGE/EYE IRRITATION
Respiratory or skin sensitisation
Patch test on human volunteers did not demonstrate sensitisation properties.
CARCINOGENICITY
IARC: No component of this product present at levels greater than or equal to 0.1%
is identified as probable, possible or confirmed human carcinogen by IARC.
GERM CELL MUTAGENICITY
No data available
Human lymphocytes
Result: negative
S. typhimurium
Result: negative
REPRODUCTIVE TOXICITY
No data available
SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE
No data available.
SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE
No data available
ASPIRATION HAZARD
No data available
ADDITIONAL INFORMATION
RTECS: SL3785000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Section 12: ECOLOGICAL INFORMATION
| Mobility : | Free |
|---|---|
| Persistence/Degradability : | Bio-degradable |
| Bio-accumulation : | none |
| Eco-toxicity : | none |
| RESULTS OF PBT AND VPVB ASSESSMENT | |
| This substance/mixture contains no components considered to be persistent, bio accumulative and toxic (PBT), or very persistent and very bio accumulative (vPvB) at levels of 0.1% or higher. |
Section 13: DISPOSAL CONSIDERATIONS
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
WASTE TREATMENT METHODS
PRODUCT
Offer surplus and non-recyclable solutions to a licensed disposal company.
CONTAMINATED PACKAGING
Dispose of as unused product.
Section 14: TRANSPORT INFORMATION
| References : | Not a DOT controlled material (United States). |
|---|---|
| UN PROPER SHIPPING NAME | |
| ADR/RID : | Not dangerous goods |
| IMDG : | Not dangerous goods |
| IATA : | Non-Regulated as per IATA |
| Special Provisions for Transport: | By Road/Air/Sea. |
| ENVIRONMENTAL HAZARDS | |
| ADR/RID : | No |
| IMDG Marine pollutant : | No |
| IATA : | No |
Section 15: OTHER REGULATORY INFORMATION
| SAFETY, HEALTH AND ENVIRONMENTAL REGULATIONS/LEGISLATION SPECIFIC FOR THE SUBSTANCE OR MIXTURE | |
|---|---|
| This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. | |
| Specific International regulation : | Complies with Natural Pharmaceutical Regulations. |
| Hazard symbols : | Not applicable. |
| CHEMICAL SAFETY ASSESSMENT | |
| For this product a chemical safety assessment was not carried out |
Section 16: OTHER INFORMATION
| Specific International regulation : | Not available |
|---|---|
| Other Special Considerations : | Not available. |
| Last Updated On: | 06.03.2019 |
| The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. Bio-India Biologicals (BIB) Corporation shall not be held liable for any Damage resulting from handling or from contact with the above the product. |